Mitochondria Malfunctions
The mitochondria are the centers of energy metabolism in the cell. When enough mitochondria are not functioning properly, a disease may result. Find out more about these diseases. How does someone get a mitochondrial disease? How are these diseases treated? Should you be concerned about these diseases?
Visit the General Aspects of Mitochondrial Genetic Diseases web site
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Deadly Dinitrophenal
Pharmaceutical manufacturers have tried many different weight-loss drugs. One metabolic target is the generation of heat by the mitochondria instead of the production of energy. One such drug that was tried, and subsequently banned because of fatal side effects, is Dinitrophenol. How does this drug work? What is the specific mechanism and how does this lead to weight loss? What is the potential problem and why did this drug lead to death? What do you think are other side effects? If you were unaware of the potential problems and desperate to try anything to lose weight, would you have used this drug?
Visit the Metabolism Problem Set web site
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Metabolic pathways
Click on Pathways and look at multiple diagrams of differnt metabolic pathways.
Visit the Kyoto Encyclopedia of Genes and Genomes web site
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The Citric Acid Cycle (Krebs cycle)
To explore the workings of the citric acid cycle, visit this Web site for an interactive tour of the individual reactions. Note that this site uses the term Krebs Cycle.
Visit the Chemical Reactions of the Krebs Cycle web site
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